BindingDB PrimarySearch_ki

Found 78 Enz. Inhib. hit(s) with all data for entry = 50015268

Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)

IC50: 0.700nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

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3D Structure (crystal)

Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584767(CHEMBL5069609)

IC50: 0.700nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584778(CHEMBL5080260)

IC50: 0.800nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 0.800nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 0.900nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584767(CHEMBL5069609)

IC50: 1.10nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)

IC50: 1.20nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM195875(US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-pip...)

IC50: 1.20nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 1.70nMAssay Description:Inhibition of BTK phosphorylation in human U-937 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM195861(US9670213, Compound 006 N-(3-(2-(4-methoxyphenylam...)

IC50: 1.80nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584770(CHEMBL5087793)

IC50: 2.20nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584768(CHEMBL5075594)

IC50: 2.30nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 2.70nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584766(CHEMBL5076283)

IC50: 2.70nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584762(CHEMBL5069689)

IC50: 3.10nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584765(CHEMBL5087785)

IC50: 3.5nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)

IC50: 3.5nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584775(CHEMBL5085807)

IC50: 4nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584776(CHEMBL5088574)

IC50: 4nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584775(CHEMBL5085807)

IC50: 4.40nMAssay Description:Inhibition of BTK phosphorylation in human U-937 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584773(CHEMBL5077901)

IC50: 4.5nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584771(CHEMBL5086054)

IC50: 4.80nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584766(CHEMBL5076283)

IC50: 5.10nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)

IC50: 5.30nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584764(CHEMBL5083645)

IC50: 9.10nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)

IC50: 10nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584769(CHEMBL5089841)

IC50: 11nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584768(CHEMBL5075594)

IC50: 11nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584780(CHEMBL5094370)

IC50: 15nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 17nMAssay Description:Inhibition of EGFR phosphorylation in human A549 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584764(CHEMBL5083645)

IC50: 18nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584762(CHEMBL5069689)

IC50: 18nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584765(CHEMBL5087785)

IC50: 22nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584763(CHEMBL5087214)

IC50: 25nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584774(CHEMBL5077665)

IC50: 31nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584778(CHEMBL5080260)

IC50: 34nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)

IC50: 38nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584779(CHEMBL5076601)

IC50: 39nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM195881(US9670213, Compound 026 N-(3-(2-(4-methoxyphenylam...)

IC50: 46nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584777(CHEMBL5081433)

IC50: 83nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584772(CHEMBL5076743)

IC50: 92nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase BTK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50557486(CHEMBL4747506)

IC50: 101nMAssay Description:Inhibition of human BTK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584762(CHEMBL5069689)

IC50: 112nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584775(CHEMBL5085807)

IC50: 118nMAssay Description:Inhibition of EGFR phosphorylation in human A549 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584766(CHEMBL5076283)

IC50: 119nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584764(CHEMBL5083645)

IC50: 122nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584763(CHEMBL5087214)

IC50: 130nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584770(CHEMBL5087793)

IC50: 137nMAssay Description:Inhibition of GST-tagged human EGFR (668 to 1210 residues) expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate incubated...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50584763(CHEMBL5087214)

IC50: 139nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)

IC50: 179nMAssay Description:Inhibition of ITK phosphorylation in human Jurkat cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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