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Found 77 Enz. Inhib. hit(s) with all data for entry = 50018682
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50611363(CHEMBL2408776)
Affinity DataKi:  44nMAssay Description:Binding affinity to LCK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50611368(CHEMBL5274907)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of human recombinant FGFR3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of human recombinant FGFR1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 uM ATP by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))TBA
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM194820(US9206184, 1 | US9206184, 2)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant FGFR2 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50611369(CHEMBL5283460)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50258974(CHEMBL4090601)
Affinity DataIC50: <1nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant FGFR2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611355(CLN-081 | CLN081 | Cln 081 | Cln-081 | TAS-6417 | ...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))TBA
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant FGFR2 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant FGFR4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant FGFR3 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))TBA
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50: <3nMAssay Description:Inhibition of His-tagged LCK (62 to 509 residues) (unknown origin) expressed in Sf9 insect cells at 10 uM using poly (Glu, Tyr) 4:1 as substrate incu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50: <3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50611360(CHEMBL5276925)
Affinity DataIC50:  3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50504103(CHEMBL4463714)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50: <4nMAssay Description:Inhibition of recombinant wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50611362(CHEMBL5276538)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant GST-tagged RET (unknown origin) using EAIYAAPFKKK as substrate in the presence of ATP of 100 uM by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))TBA
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  5nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM25116(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))TBA
LigandPNGBDBM25116(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  6nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50388180(CHEMBL2057912)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of recombinant BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM161389(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))TBA
LigandPNGBDBM50611357(CHEMBL5286014)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of LYN (unknown origin) at 1 uM by kinase-profiling analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50611367(CHEMBL5277058)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50611366(CHEMBL5287716)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50:  12nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))TBA
LigandPNGBDBM50611357(CHEMBL5286014)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM194820(US9206184, 1 | US9206184, 2)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant FGFR1 in the presence of ATP at 0.16 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50258974(CHEMBL4090601)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM194820(US9206184, 1 | US9206184, 2)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant FGFR3 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50413999(CGP77675 | CHEMBL475584)
Affinity DataIC50:  20nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Homo sapiens (Human))TBA
LigandPNGBDBM50611358(CHEMBL5285282)
Affinity DataIC50:  23nMAssay Description:Inhibition of HER3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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