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Found 16 Enz. Inhib. hit(s) with all data for entry = 50018990
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
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TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8...More data for this Ligand-Target Pair
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TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
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TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
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TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 ...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu5 in human HEK cells assessed as increase in calcium flux preincubated for 2.5 mins followed by glu...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu3 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 2(Rattus norvegicus)TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu2 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
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LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu1 in human HEK cells assessed assessed as increase in calcium flux preincubated for 2.5 mins follow...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  197nMAssay Description:Positive allosteric modulator activity at rat mGlu4 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human mGlu6 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu7 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  65nMAssay Description:Positive allosteric modulator activity at human mGlu4 in Chinese hamster CHO cells co-expressing Gqi5 assessed as increase in calcium flux preincubat...More data for this Ligand-Target Pair
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TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-A (unknown origin)More data for this Ligand-Target Pair
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TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to MAO-B (unknown origin)More data for this Ligand-Target Pair
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TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))TBA
LigandPNGBDBM368514(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu8 in human HEK cells co-expressing GRIK assessed as increase in by thallium flux preincubated for 2...More data for this Ligand-Target Pair
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