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Found 9 Enz. Inhib. hit(s) with all data for entry = 50019145
TargetDCN1-like protein 1(Homo sapiens)TBA
LigandPNGBDBM50525354(CHEMBL4517307)
Affinity DataKi:  12nMAssay Description:Binding affinity to DCN1 (unknown origin) assessed as inhibition of constant by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human EGFR L858R mutant (669 to 1210 residues) expressed in Sf21 insect cells using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate incubated fo...More data for this Ligand-Target Pair
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins...More data for this Ligand-Target Pair
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LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 c...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  17nMAssay Description:Inhibition of C-terminal His6 tagged full length recombinant human CDK9/full length human Cyclin T1 expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  27nMAssay Description:Inhibition of full length human CDK4/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH ...More data for this Ligand-Target Pair
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LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant full length human C-terminal His6-tagged CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombi...More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal GST-tagged full length human BTK (2 to 659 residues) expressed in Sf21 insect cells using 5-FAM-EAIYAAPFAKKK as substrate in...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  133nMAssay Description:Inhibition of full length human CDK6/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH ...More data for this Ligand-Target Pair
In DepthDetails PubMed