Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 783 Enz. Inhib. hit(s) with all data for entry = 875
LigandPNGBDBM247849(US10112931, Example 456 | US9434719, 456 | US96886...)
Affinity DataIC50:  1nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM296116((R)-3-(2-(((S)-1-(5-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataIC50: <2.29nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247707(US10112931, Example 309 | US9434719, 309 | US96886...)
Affinity DataIC50:  3nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247707(US10112931, Example 309 | US9434719, 309 | US96886...)
Affinity DataIC50:  3nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247707(US10112931, Example 309 | US9434719, 309 | US96886...)
Affinity DataIC50:  4nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247707(US10112931, Example 309 | US9434719, 309 | US96886...)
Affinity DataIC50:  4nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247567(US10112931, Example 133 | US9434719, 133 | US96886...)
Affinity DataIC50:  4nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247614(US10112931, Example 216 | US9434719, 216 as TFA sa...)
Affinity DataIC50:  4nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247873(US10112931, Example 480 | US9434719, 480 | US96886...)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247494(BDBM295678 | US9434719, 28)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247525(US10112931, Example 63 | US9434719, 63 | US9688672...)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247590(US10112931, Example 179 | US9434719, 179 | US96886...)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247599(US10112931, Example 197 | US9434719, 197 | US96886...)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247601(US10112931, Example 201 | US9434719, 201 | US96886...)
Affinity DataIC50:  5nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247785(US10112931, Example 388 | US9434719, 388 as TFA sa...)
Affinity DataIC50:  6nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247580(US10112931, Example 159 | US9434719, 159 | US96886...)
Affinity DataIC50:  6nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247760(US10112931, Example 363 | US9434719, 363 as TFA sa...)
Affinity DataIC50:  7nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
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LigandPNGBDBM247782(US10112931, Example 385 | US9434719, 385 | US96886...)
Affinity DataIC50:  7nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247567(US10112931, Example 133 | US9434719, 133 | US96886...)
Affinity DataIC50:  7nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247590(US10112931, Example 179 | US9434719, 179 | US96886...)
Affinity DataIC50:  7nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM296116((R)-3-(2-(((S)-1-(5-(2-fluoro-3-(trifluoromethyl)p...)
Affinity DataIC50:  8nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247526(US10112931, Example 64 | US9434719, 64 | US9688672...)
Affinity DataIC50:  8nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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In DepthDetails US Patent

LigandPNGBDBM247602(US10112931, Example 203 | US9434719, 203 | US96886...)
Affinity DataIC50:  8nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247701(US10112931, Example 303 | US9434719, 303 | US96886...)
Affinity DataIC50:  9nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247760(US10112931, Example 363 | US9434719, 363 as TFA sa...)
Affinity DataIC50:  9nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247624(US10112931, Example 226 | US9434719, 226 as TFA sa...)
Affinity DataIC50:  9nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247698(US10112931, Example 300 | US9434719, 300 | US96886...)
Affinity DataIC50:  10nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247856(US10112931, Example 463 | US9434719, 463 | US96886...)
Affinity DataIC50:  10nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247496(US10112931, Example 32 | US9434719, 30 | US9434719...)
Affinity DataIC50:  10nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247594(US10112931, Example 187 | US9434719, 187 | US96886...)
Affinity DataIC50:  10nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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In DepthDetails US Patent

LigandPNGBDBM247597(US10112931, Example 193 | US9434719, 193)
Affinity DataIC50:  10nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247859(US10112931, Example 466 | US9434719, 466 | US96886...)
Affinity DataIC50:  11nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
LigandPNGBDBM247568(US10112931, Example 135 | US9434719, 135 | US96886...)
Affinity DataIC50:  11nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247605(US10112931, Example 207 | US9434719, 207 as TFA sa...)
Affinity DataIC50:  11nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM175219(US10112931, Example 213 | US9688672, Example 213)
Affinity DataIC50:  11nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247614(US10112931, Example 216 | US9434719, 216 as TFA sa...)
Affinity DataIC50:  11nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247636(US10112931, Example 238 | US9434719, 238 as TFA sa...)
Affinity DataIC50:  12nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247869(US10112931, Example 476 | US9434719, 476 as TFA sa...)
Affinity DataIC50:  12nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM174784(US10112931, Example 85 | US9688672, Example 85)
Affinity DataIC50:  12nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247570(US10112931, Example 139 | US9434719, 139 | US96886...)
Affinity DataIC50:  12nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM247576(US10112931, Example 151 | US9434719, 151)
Affinity DataIC50:  12nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247615(US10112931, Example 217 | US9434719, 217 as TFA sa...)
Affinity DataIC50:  12nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247863(US10112931, Example 470 | US9434719, 470)
Affinity DataIC50:  12.8nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247635(US10112931, Example 237 | US9434719, 237 as TFA sa...)
Affinity DataIC50:  13nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247955(US10112931, Example 321 | US9434719, 321 as TFA sa...)
Affinity DataIC50:  13nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM247513(US10112931, Example 51 | US9434719, 51 | US9688672...)
Affinity DataIC50:  13nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM174784(US10112931, Example 85 | US9688672, Example 85)
Affinity DataIC50:  13nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM174788(US10112931, Example 91 | US9688672, Example 91)
Affinity DataIC50:  13nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247626(US10112931, Example 228 | US9434719, 228 | US96886...)
Affinity DataIC50:  14nMpH: 7.4 T: 25°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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LigandPNGBDBM247661(US10112931, Example 263 | US9434719, 263 as TFA sa...)
Affinity DataIC50:  14nMpH: 7.5 T: 25°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
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In DepthDetails US Patent

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