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Found 3 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50224213'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataKi:  27nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224213(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed