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Found 35 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A2b' and Ligand = 'BDBM21220'
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  262nMAssay Description:Displacement of [3H]MRE-2029F20 from human recombinant adenosine A2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  330nMMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  570nMAssay Description:Displacement of [3H]MRS-1754 from human recombinant adenosine A2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  760nMAssay Description:Inhibition of [3H]DPCPX binding to human adenosine A2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  884nMAssay Description:Displacement of [125I]ABOPX from human adenosine A2B receptor in HEK cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]PSB-603 from human adenosine receptor A2B in CHO cells after 75 mins by liquid scintillation methodMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Rattus norvegicus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  2.60E+3nMAssay Description:Activity against Adenosine A2B receptor as cAMP production in VA-13 cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  250nMAssay Description:Relative efficacy against phenylephrine precontracted tissue relaxation in Guinea pig aortaMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  331nMAssay Description:Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  155nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  1.51E+3nMAssay Description:Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for ...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 min...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  316nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human A2B adenosine receptor by cell based assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  43nMAssay Description:Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of ...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by ...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  440nMAssay Description:Potency against cAMP formation in CHO cells expressing recombinant human A2B receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  104nMAssay Description:Agonistic activity against human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  3.10E+3nMAssay Description:Effective concentration for cAMP production in CHO-KI cells stably transfected with human adenosine A2B receptor cDNAMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  2.40E+3nMAssay Description:Receptor stimulated adenylyl cyclase activity in CHO cells expressing human recombinant Adenosine A2B receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  1.48E+4nMAssay Description:Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase r...More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  330nMAssay Description:Agonist activity at human recombinant adenosine receptor A2b by cAMP assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  7.14E+6nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  140nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataEC50:  160nMAssay Description:Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP levelsMore data for this Ligand-Target Pair