Report error Found 17 Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit B' and Ligand = 'BDBM50226181'
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Inhibition of Escherichia coli H560 DNA gyrase B ATPase activity after 30 mins by ammonium molybdate/malachite green-based phosphate detection assayMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase ATPase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining based fl...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B preincubated for 10 mins followed by ATP addition measured after 30 mins by purine nucleoside phosph...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium smegmatis 155 6His-tagged DNA gyrase B catalytic domain ATPase activity expressed in Escherichia coli BL21 (DE3) pLysS ce...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATPase activityMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining ba...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli DNA gyrase B ATP binding site assessed as reduction in supercoiling of relaxed pNO1 DNA after 30 mins in presence of b...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of Escherichia coli C-terminal His6-tagged DNA gyrase B expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by ATP a...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of 6-His-tagged Mycobacterium smegmatis GyrB expressed in Escherichia coli BL21 (DE3) pLysS cells incubated for 100 mins in presence of AT...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in ATPase activity incu...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Redx Pharma
Curated by ChEMBL
Redx Pharma
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of supercoiling activity using relaxed pBR322 plasmid as substrate after 3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B expressed in BL21(DE3)pLysS cells assessed as inhibition of DNA supercoiling activity in presence ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
R. C. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataKd: 7nMAssay Description:Binding affinity to Escherichia coli H560 DNA gyrase BMore data for this Ligand-Target Pair