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Found 5 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM18258'
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18258(5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  110nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

LigandPNGBDBM18258(5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  160nMpH: 7.4 T: 2°CAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM18258(5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM18258(5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  3.55E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM18258(5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  9.58E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed