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Found 9 Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 1' and Ligand = 'BDBM50195239'
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.40nMAssay Description:Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50195239(CHEMBL3972563 | US10287258, Example 29 | US1066924...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed