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Found 3 Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase TTK' and Ligand = 'BDBM329340'
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)
Affinity DataIC50: <1nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM329340((2R)—N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carb...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed