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Found
1
Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [17-125]' and Ligand = 'BDBM224187'
Target
E3 ubiquitin-protein ligase Mdm2 [17-125]
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM224187
(5-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylc...)
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Affinity Data
IC50: 0.825nM
T: 2°C
Assay Description:
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...
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Target Info
PDB
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Ligand Info
PC cid
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Details
US Patent
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