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Found
1
Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2 [17-125]' and Ligand = 'BDBM224288'
Target
E3 ubiquitin-protein ligase Mdm2 [17-125]
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM224288
(5-(6-(5-chloropyridin-3-yl)-7-(1- ((trans)-4-methy...)
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Affinity Data
IC50: 0.620nM
T: 2°C
Assay Description:
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...
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Target Info
PDB
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Ligand Info
PC cid
PC sid
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Details
US Patent
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