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Found 3 Enz. Inhib. hit(s) with Target = 'Egl nine homolog 1' and Ligand = 'BDBM242558'
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM242558(US9422240, 1-353)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PHD2 using FITC-HIF1-alpha as substrate after 10 mins in presence of 2-oxoglutarate by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM242558(US9422240, 1-353)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat PHD2 using FITC-HIF1-alpha as substrate after 10 mins in presence of 2-oxoglutarate by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM242558(US9422240, 1-353)
Affinity DataIC50:  43nMpH: 7.5Assay Description:The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...More data for this Ligand-Target Pair
In DepthDetails US Patent