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Found 4 Enz. Inhib. hit(s) with Target = 'Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]' and Ligand = 'BDBM536231'
LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.75E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataIC50:  1.76E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataKd:  4.24E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536231((2R)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,...)
Affinity DataKd:  4.69E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent