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Found 4 Enz. Inhib. hit(s) with Target = 'Endothelial lipase' and Ligand = 'BDBM187285'
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM187285(US9169240, 25)
Affinity DataIC50:  86nMpH: 8.0Assay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM187285(US9169240, 25)
Affinity DataIC50:  90nMAssay Description:Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM187285(US9169240, 25)
Affinity DataIC50:  200nMAssay Description:Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM187285(US9169240, 25)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed