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Found 2 Enz. Inhib. hit(s) with Target = 'GTPase KRas [G12C]' and Ligand = 'BDBM535466'
TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535466(US11236068, Example 63a | US11236068, Example 63b)
Affinity DataIC50:  7nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535466(US11236068, Example 63a | US11236068, Example 63b)
Affinity DataIC50:  160nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent