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Enz. Inhib. hit(s) with Target = 'GTPase KRas [G12D]' and Ligand = 'BDBM617339'
Target
GTPase KRas [G12D]
(Homo sapiens (Human))
Mirati Therapeutics
US Patent
Ligand
BDBM617339
(US20230279025, Example 460)
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Affinity Data
IC50: 0.0270nM
Assay Description:
This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...
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