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Found 6 Enz. Inhib. hit(s) with Target = 'Geranylgeranyl pyrophosphate synthase' and Ligand = 'BDBM25259'
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant GGPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant GGPPS using [14C]-IPP as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed