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Found 3 Enz. Inhib. hit(s) with Target = 'Geranylgeranyl pyrophosphate synthase' and Ligand = 'BDBM50520638'
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50520638(CHEMBL4471037 | US11279719, Example I-18)
Affinity DataIC50:  37nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50520638(CHEMBL4471037 | US11279719, Example I-18)
Affinity DataIC50: <100nMAssay Description:The assay was based on a literature procedure (Kavanagh, et al. J. Biol. Chem., 2006, 281, 22004-22012) with minor modifications. All assays were run...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50520638(CHEMBL4471037 | US11279719, Example I-18)
Affinity DataIC50:  100nMAssay Description:Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed