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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Ileal sodium/bile acid cotransporter' and Ligand = 'BDBM50434846'
TargetIleal sodium/bile acid cotransporter(Mouse)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50:  54nMT: 25°CAssay Description:On the day of the uptake experiment, 10 mM HEPES was added to Hank's Balanced Salt Solution, and the pH was adjusted to 7.4 with TRIS (HBSSH). The as...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetIleal sodium/bile acid cotransporter(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50:  54nMAssay Description:Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed