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Found 3 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM50610369'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))TBA
LigandPNGBDBM50610369(CHEMBL5277174)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of GCase in patient derived fibroblast cells using 5'pentafluorobenzoylaminofluorescein-di-beta-D-glucoside as substrate assessed as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))TBA
LigandPNGBDBM50610369(CHEMBL5277174)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant GCase (unknown origin) using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate at pH 4.5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))TBA
LigandPNGBDBM50610369(CHEMBL5277174)
Affinity DataEC50:  5.60nMAssay Description:Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate assess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed