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Report error Found 15 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM136055'
TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  2nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  3nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  6nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  7nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  16nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  38nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  50nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  83nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  83nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  88nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  136nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  153nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM136055(US8853203, 99 | US9650377, Example 99s)
Affinity DataIC50:  220nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In DepthDetails US Patent