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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Mucosa-associated lymphoid tissue lymphoma translocation protein 1' and Ligand = 'BDBM355922'
LigandPNGBDBM355922((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Affinity DataIC50:  0.0130nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM355922((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM355922((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Affinity DataIC50:  60nMAssay Description:Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM355922((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed