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Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50544854'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544854(CHEMBL4646412 | US11292781, Compound T36)
Affinity DataIC50:  132nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544854(CHEMBL4646412 | US11292781, Compound T36)
Affinity DataIC50:  160nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544854(CHEMBL4646412 | US11292781, Compound T36)
Affinity DataIC50:  161nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent