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Report error Found 3 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM50544860'
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544860(CHEMBL4633864 | US11292781, Compound T56)
Affinity DataIC50:  46nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544860(CHEMBL4633864 | US11292781, Compound T56)
Affinity DataIC50:  51nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544860(CHEMBL4633864 | US11292781, Compound T56)
Affinity DataIC50:  60nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed