Found 5 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50110164' TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School of Medicine
Curated by ChEMBL
Okayama University Graduate School of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School of Medicine
Curated by ChEMBL
Okayama University Graduate School of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.71E+4nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School of Medicine
Curated by ChEMBL
Okayama University Graduate School of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.25E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School of Medicine
Curated by ChEMBL
Okayama University Graduate School of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.15E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School of Medicine
Curated by ChEMBL
Okayama University Graduate School of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.32E+5nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
