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Found 4 Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 9' and Ligand = 'BDBM50609095'
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))TBA
LigandPNGBDBM50609095(CHEMBL5280306)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PCSK9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))TBA
LigandPNGBDBM50609095(CHEMBL5280306)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human PCSK9 preincubated for 30 mins followed by EGF(A) addition and measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))TBA
LigandPNGBDBM50609095(CHEMBL5280306)
Affinity DataEC50:  250nMAssay Description:Inhibition of PCSK9 mediated LDLR degradation in human HepG2 cells assessed as restoration of LDLRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))TBA
LigandPNGBDBM50609095(CHEMBL5280306)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human PCSK9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed