Found 9 Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-3' and Ligand = 'BDBM25017' TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 22.6nMAssay Description:LANCE (Lanthanide Chelate Excite) Eu time-resolved fluorescence resonance energy transfer (TR-FRET) kinase assay (PerkinElmer) was performed in 384-w...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of RSK2 (unknown origin) using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of His6-tagged human RSK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK-peptide as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] labe...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of RSK2 (unknown origin) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK a substrate by [32P] gammaATP assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of full length human GST-tagged RSK2 using Ulight-rpS6 as substrate incubated for 1 hr in presence of ATP by TR FRET assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
Affinity DataEC50: 2.60E+3nMAssay Description:Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assayMore data for this Ligand-Target Pair
