Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase/endoribonuclease IRE1' and Ligand = 'BDBM50526270' TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 218nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataEC50: 143nMAssay Description:Activation of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin)-dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1...More data for this Ligand-Target Pair
