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Found 5 Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 3' and Ligand = 'BDBM50545650'
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  18nMAssay Description:Inhibition of IFN-alpha induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IFN-alpha stimulation and meas...More data for this Ligand-Target Pair
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  33nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-6 stimulation and measured after...More data for this Ligand-Target Pair
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  40nMAssay Description:Inhibition of IL-2 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-2 stimulation and measured after...More data for this Ligand-Target Pair
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  84nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-23 stimulation and measured aft...More data for this Ligand-Target Pair
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  304nMAssay Description:Inhibition of GM-CSF induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by GM-CSF stimulation and measured a...More data for this Ligand-Target Pair
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