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Found 5 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha' and Ligand = 'BDBM145227'
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) by PatchXpress methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human Nav1.5 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of full length human NaV1.5 expressed in HEK293 cells coexpressing Nav beta1 subunit assessed as decrease in sodium current amplitude by P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.90E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.91E+3nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In DepthDetails US Patent