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Found 6 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 1' and Ligand = 'BDBM313178'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataIC50:  119nMAssay Description:GTPγS:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataIC50:  119nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataIC50:  119nMAssay Description:In vitro characterization of biological activity of the examples was conducted on synthetically prepared samples of the phosphorylated compounds. S1P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataEC50:  49nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataEC50:  49nMAssay Description:GTPγS:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313178(US10166249, Example 695 | US10709719, Example 696 ...)
Affinity DataEC50:  1.20nMAssay Description:GTPγS:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 μl/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent