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Report error Found 5 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18753'
TargetThymidylate synthase(Lactobacillus casei)
University of California San Francisco

LigandPNGBDBM18753(4,4-bis(3-bromo-4-hydroxyphenyl)-10-chloro-3-oxatr...)
Affinity DataKi:  800nM ΔG°:  -34.2kJ/molepH: 7.4 T: 20°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli (strain K12))
University of California San Francisco

LigandPNGBDBM18753(4,4-bis(3-bromo-4-hydroxyphenyl)-10-chloro-3-oxatr...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.2kJ/molepH: 7.4 T: 20°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Cryptococcus neoformans)
University of California San Francisco

LigandPNGBDBM18753(4,4-bis(3-bromo-4-hydroxyphenyl)-10-chloro-3-oxatr...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.2kJ/molepH: 7.4 T: 20°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Pneumocystis carinii)
University of California San Francisco

LigandPNGBDBM18753(4,4-bis(3-bromo-4-hydroxyphenyl)-10-chloro-3-oxatr...)
Affinity DataKi:  2.80E+4nM ΔG°:  -25.6kJ/molepH: 7.4 T: 20°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Human)
University of California San Francisco

LigandPNGBDBM18753(4,4-bis(3-bromo-4-hydroxyphenyl)-10-chloro-3-oxatr...)
Affinity DataKi: >2.45E+5nM ΔG°: >-20.3kJ/molepH: 7.4 T: 20°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed