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Report error Found 6 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18772'
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  800nM ΔG°:  -34.2kJ/molepH: 7.0 T: 20°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli (strain K12))
UniversitÀ

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.2kJ/molepH: 7.0 T: 20°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  4.10E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Pneumocystis carinii)
UniversitÀ

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  2.80E+4nM ΔG°:  -25.6kJ/molepH: 7.0 T: 20°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Human)
Unimore

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi: >2.45E+5nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Human)
Unimore

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi: >2.45E+5nM ΔG°: >-20.3kJ/molepH: 7.0 T: 20°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed