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Report error Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM467364'
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467364((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-chloro-4-phe...)
Affinity DataKi:  12nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467364((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-chloro-4-phe...)
Affinity DataIC50:  13nMAssay Description:Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467364((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-chloro-4-phe...)
Affinity DataIC50:  25.1nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent