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Report error Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM109867'
TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US20240150367, Compound 5 | US8609647, 27 | US8609...)
Affinity DataIC50:  3.30nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US20240150367, Compound 5 | US8609647, 27 | US8609...)
Affinity DataIC50:  4nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US20240150367, Compound 5 | US8609647, 27 | US8609...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US20240150367, Compound 5 | US8609647, 27 | US8609...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US20240150367, Compound 5 | US8609647, 27 | US8609...)
Affinity DataIC50:  88nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In DepthDetails US Patent