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Found
1
Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11' and Ligand = 'BDBM408096'
Target
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM408096
(US10336774, Example 90)
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Affinity Data
IC50: 4nM
Assay Description:
SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...
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Target Info
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Ligand Info
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US Patent
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