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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 0.980nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen-Cilag
Curated by ChEMBL
Janssen-Cilag
Curated by ChEMBL
Affinity DataIC50: 1.58nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected insect Sf9 cells using [3H]cAMP as substrate after 60 mins by scintillation co...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Abbvie
US Patent
Abbvie
US Patent
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
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