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Report error Found 3 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A' and Ligand = 'BDBM14774'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of human recombinant PDE4A using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of human PDE4A4 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank