TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Oryctolagus cuniculus)
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in Rabbit cardiac muscle.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Oryctolagus cuniculus)
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in Rabbit cardiac muscle.More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of vasopressin induced calcium immobilization in human V1a receptor expressing cellsMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Ability to displace [3H]-arginine vasopressin in cloned human V2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Ability to displace [3H]-arginine vasopressin in cloned human V2 receptorMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Ability to displace [3H]-arginine vasopressin in cloned human V2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 10nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibitory activity aginst SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibitory activity towards human SGLT2 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Ability to displace [3H]-arginine vasopressin in cloned human V2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Ability to displace [3H]-arginine vasopressin in cloned human V2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of vasopressin induced cAMP accumulation in human V2 receptor expressing cellsMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 16nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:For the RORγt construct used in the ThermoFluorŪ assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma [258-518,Y502F](Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 18nMAssay Description:The reporter assay was performed by transiently transfecting HEK293T cells with 5 μg of pBIND-RORγt LBD or pBIND-RORγt LBD-AF2 and 5 &...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...More data for this Ligand-Target Pair