Compile Data Set for Download or QSAR
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Found 92 of ic50 for UniProtKB: Q13464
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196700(5-((3-(3-(prop-1-en-2-yl)benzyl)cyclohexyl)methyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196694(CHEMBL225166 | N-(1-(thiophen-3-ylmethyl)piperidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196718(CHEMBL373512 | N-(1-(thiophen-2-ylmethyl)piperidin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196692(CHEMBL388516 | N-(1-(4-methylbenzyl)piperidin-3-yl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196695(CHEMBL224510 | N-(1-(3,4-difluorobenzyl)piperidin-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196690(CHEMBL224535 | N-(1-(4-aminobenzyl)piperidin-3-yl)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196711(1-benzyl-3-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196689(CHEMBL224166 | N-(1-((1H-pyrrol-2-yl)methyl)piperi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196682(CHEMBL426925 | N-(1-(4-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50519606(CHEMBL4448462)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ROCK incubated for 20 mins followed by 33P ATP after 120 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  12nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196707(CHEMBL390837 | N-(1-(2-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196712(CHEMBL225637 | N-(1-(4-methoxybenzyl)piperidin-3-y...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196704(1-benzyl-N-(1H-5-indazolyl)piperidine-3-carboxamid...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196728(CHEMBL389168 | N-(1-(3-chlorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196687(1-(2,6-dichlorobenzyl)-3-(1H-indazol-5-yl)urea | 1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196725(CHEMBL224885 | N-(1-benzyl-3-piperidyl)-N-(1H-5-in...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196698(CHEMBL390389 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196725(CHEMBL224885 | N-(1-benzyl-3-piperidyl)-N-(1H-5-in...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196686(CHEMBL427245 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  24nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196688(CHEMBL224509 | N-(1-(4-fluorobenzyl)piperidin-3-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197913((3R)-N-[1-(3-aminobenzyl)-3-pyrrolidyl]-N-(5-isoqu...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196708(CHEMBL386937 | N-(1-benzyl-3-pyrrolidyl)-N-(1H-5-i...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196699(CHEMBL390736 | N-(1-(3-aminobenzyl)piperidin-3-yl)...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196679(CHEMBL388742 | N-(1-(2-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506928(CHEMBL4469434)
Affinity DataIC50:  56nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196706(CHEMBL225167 | N-(1-(furan-2-ylmethyl)piperidin-3-...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197915(CHEMBL223815 | N-(1-(3-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197914(CHEMBL375556 | N-(1-(4-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197922(CHEMBL224361 | N1-cyclopropyl-N4-(5-isoquinolyl)-1...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196683(CHEMBL224746 | N-(1-(pyridin-3-ylmethyl)piperidin-...)
Affinity DataIC50:  72nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197907(CHEMBL387954 | N-(1-(2,6-difluorobenzyl)pyrrolidin...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506932(CHEMBL2006299)
Affinity DataIC50:  75nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196685(CHEMBL389622 | N-(1-(3,5-dimethoxybenzyl)piperidin...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196681(1-(2,6-difluorobenzyl)-3-(1H-indazol-5-yl)urea | C...)
Affinity DataIC50:  85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196702(CHEMBL427254 | N-(1-(2-aminobenzyl)piperidin-3-yl)...)
Affinity DataIC50:  85nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196691(CHEMBL389915 | N-(1-(4-nitrobenzyl)piperidin-3-yl)...)
Affinity DataIC50:  87nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506931(CHEMBL4465725)
Affinity DataIC50:  94nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197900(CHEMBL223336 | N-(1-(4-fluorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  95nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197901(CHEMBL389926 | N-(1-(2-chlorobenzyl)pyrrolidin-3-y...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196696(1-benzyl-4-piperidyl-(1H-5-indazolyl)ether | 5-(1-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506921(CHEMBL4459800)
Affinity DataIC50:  116nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196684(1-benzyl-N-(1H-5-indazolyl)piperidine-4-carboxamid...)
Affinity DataIC50:  136nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197919(CHEMBL224505 | N-(1-benzyl-4-piperidyl)-N-(5-isoqu...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM107898(CHEMBL373487 | US8604218, 1.049)
Affinity DataIC50:  150nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506945(CHEMBL4474946)
Affinity DataIC50:  173nMAssay Description:Inhibition of ROCK1/2 in human PANC1 cells assessed as reduction in MYPT1 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50196720(CHEMBL225168 | N-[1-(3-furylmethyl)-3-piperidyl]-N...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1/2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50197920(CHEMBL266512 | N1-propyl-N4-(5-isoquinolyl)-1,4-cy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Rho kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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