Affinity DataIC50: 0.460nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human BTK-A using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trademark) MSA (commercially available kit manufactured by Carna Biosciences, Inc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of human BTK C481S mutant using phosphorylated substrate in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human TEC (359 - 631 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in BTK phosphorylation at Tyr223 residue incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction of IgM stimulated PLCgamma2 (Y1217) phosphorylation after 24 hrs by western blot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) in presence of 1 mM ATP by microplate reader assayMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human full-length BMX (1 to 675 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:The kinase activity was measured using QuickScout Screening Assist (trade mark) MSA (commercially available kit manufactured by Carna Biosciences, In...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK in human whole blood assessed as activation of anti-IgM-induced CD69 expression by flow cytometry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of human ITK (2 - 620 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 221nMAssay Description:Inhibition of human DDR1 (444 - 876 residues) expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 291nMAssay Description:Inhibition of human full length SRC expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
TargetMuscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 306nMAssay Description:Inhibition of human MUSK expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 8.54E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2CD6 (unknown origin)More data for this Ligand-Target Pair