TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity against human NK3 receptor expressed in HEK293 cells assessed as inhibition of increase of intracellular calcium level by fluores...More data for this Ligand-Target Pair
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 16.6nMAssay Description:Antagonist activity against human NK3 receptor expressed in HEK293 cells assessed as inhibition of NKB-induced increase of intracellular calcium leve...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair