BindingDB PrimarySearch

Found 5 of ic50 for monomerid = 50239545

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

BDBM50239545(CHEMBL4092688)

IC50: 0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

BDBM50239545(CHEMBL4092688)

IC50: 7.90nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

BDBM50239545(CHEMBL4092688)

IC50: 40nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 60 mins followed by Anti...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

BDBM50239545(CHEMBL4092688)

IC50: 200nMAssay Description:Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

BDBM50239545(CHEMBL4092688)

IC50: 1.26E+3nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 5 hits

Targets 5▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
Publications 1▿
- J Med Chem 60: 5057-5071 (2017) 5
Institutions 1▿
- Astrazeneca 5
Affinity: 0.63 to 1.3E+3 nM▿
- IC50 5
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0