Affinity DataIC50: 400nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:TP_TRANSPORTER: drug resistance (vincristine) in AML-2/D100 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.37E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
Affinity DataIC50: 2.58E+3nMAssay Description:TP_TRANSPORTER: drug resistance (paclitaxel) in HCT15/CL02 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux (Daunorubicin: ? uM) in G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by calcein AM assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.52E+3nMAssay Description:TP_TRANSPORTER: drug resistance (paclitaxel) in MES-SA/DX5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of Pgp by daunorubicin accumulation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Pgp by daunorubicin accumulation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of human Pgp in A2780 cells after 30 mins by Hoechst 33342 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of P-glycoprotein by Hoechst assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 8.44E+3nMAssay Description:TP_TRANSPORTER: transepithelial transport of fexofenadine in Caco-2 cellsMore data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: 9.66E+3nMAssay Description:Inhibition of human MRP1 in human 2008 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.89E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of chloroquine-resistant Plasmodium falciparum Dd2 CRT expressed in Xenopus laevis oocytes assessed as reduction in [3H]-chloroquine uptak...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of chloroquine-resistant Plasmodium falciparum Dd2 CRT expressed in Xenopus laevis oocyte assessed as inhibition of [3H]chloroquine uptake...More data for this Ligand-Target Pair
Affinity DataIC50: 3.82E+4nMAssay Description:TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+4nMAssay Description:TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Membrane Research Group Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: efflux of Hoechst33342 in BCRP-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.91E+4nMAssay Description:TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.79E+5nMAssay Description:TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
University Of Bonn
Curated by ChEMBL
University Of Bonn
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human MRP2 expressed in dog MDCK2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.47E+5nMAssay Description:TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Membrane Research Group Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Membrane Research Group Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 5.25E+5nMAssay Description:Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+8nMAssay Description:Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assayMore data for this Ligand-Target Pair