Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 2' and Ligand = 'BDBM50092312'
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  5.40nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD2 BD2 (349 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  5.40nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 2 (349 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  10nMAssay Description:Binding affinity to human recombinant BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  17nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD2 BD1 (72 to 205 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  17nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 1 (72 to 205 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 25nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 2 (349 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  33nMAssay Description:Binding affinity to human recombinant BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 33nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 1 (72 to 205 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 58nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant human His6-tagged BRD2 bromodomain 2 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50092312BDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 92nMAssay Description:Inhibition of N-terminal His-tagged human recombinant BRD2 BD2 expressed in Escherichia coli BL21 (DE3) by Alpha Screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed