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Cytochrome P450 1A2(Homo sapiens (Human))
Ocean University Of China

Curated by ChEMBL

IC50: 5.57E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using isoform-specific probe substrates incubated for 15 to 30 mins by by LC-MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Targets 24▿
- Coagulation factor X 378
- Prothrombin 109
- Tissue-type plasminogen activator 71
- Vitamin K-dependent protein C 71
- Plasminogen 71
- Serine protease 1 67
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 47
- Monocarboxylate transporter 1 21
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 20
- Potassium voltage-gated channel subfamily H member 2 12
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 10
- Kallikrein-1 10
- Plasma kallikrein 9
- G-protein coupled estrogen receptor 1 4
- Cytochrome P450 2D6 4
- Cytochrome P450 3A4 4
- Estrogen receptor 3
- Serine/threonine-protein kinase mTOR 3
- Cytochrome P450 1A2 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2C19 1
- Estrogen receptor beta 1
- Cytochrome P450 2C8 1
- Cytochrome P450 2B6 1
- ...
Publications 12▿
- Bioorg Med Chem Lett 14: 989-93 (2004) 319
- Bioorg Med Chem Lett 13: 723-8 (2003) 135
- Bioorg Med Chem Lett 14: 1221-7 (2004) 107
- Bioorg Med Chem Lett 19: 2179-85 (2009) 88
- Bioorg Med Chem Lett 14: 1229-34 (2004) 78
- Bioorg Med Chem Lett 14: 983-7 (2004) 69
- J Med Chem 65: 3359-3370 (2022) 69
- Nat Chem Biol 1: 371-6 (2005) 21
- J Med Chem 63: 5865-5878 (2020) 9
- Nat Chem Biol 2: 207-12 (2006) 8
- Eur J Med Chem 202: (2020) 6
- J Biol Chem 282: 13395-401 (2007) 3
Institutions 7▿
- Millennium Pharmaceuticals 796
- University Of Cambridge 69
- Astrazeneca R&D Charnwood 21
- Ocean University Of China 9
- University Of New Mexico Health Sciences Center 8
- Ochsner Clinic 6
- Stanford University 3
Affinity: 0.012 to 5.0E+5 nM▿
- Ki 104
- IC50 802
- Kd 2
- EC50 2
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 0
Catalog Cmpds: 24