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Tyrosine-protein kinase BTK(Homo sapiens (Human))
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)

Curated by ChEMBL

BDBM50589160(CHEMBL5186944)

IC50: 33nMAssay Description:Inhibition of BTK (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair

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Filter my 1698 hits

Targets 65▿
- Epidermal growth factor receptor 300
- Glycogen phosphorylase, muscle form 161
- C5a anaphylatoxin chemotactic receptor 1 112
- Epidermal growth factor receptor [T790M] 99
- Integrin alpha-4/beta-7 97
- Integrin alpha-4/beta-1 [T112H] 67
- DCN1-like protein 1 65
- Coagulation factor X 63
- High affinity nerve growth factor receptor 62
- E3 ubiquitin-protein ligase Mdm2 55
- Macrophage colony-stimulating factor 1 receptor 47
- Prothrombin 45
- Serine protease 1 44
- Dipeptidyl peptidase 4 43
- Acetylcholinesterase 42
- Epidermal growth factor receptor [T790M,L858R] 36
- Neprilysin 31
- Integrin alpha-4/beta-1 30
- Hepatocyte growth factor receptor 29
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 25
- Diacylglycerol O-acyltransferase 1 24
- Cytochrome P450 3A4 19
- CREB-binding protein 16
- Hemagglutinin 16
- Histone acetyltransferase p300 14
- Poly [ADP-ribose] polymerase 1 14
- Vascular endothelial growth factor receptor 2 12
- Receptor protein-tyrosine kinase 10
- Cytochrome P450 1A2 8
- Cytochrome P450 2C9 8
- Cytochrome P450 2C19 8
- Cytochrome P450 2D6 8
- Potassium voltage-gated channel subfamily H member 2 8
- Androgen receptor 7
- Protein Mdm4 7
- Colony stimulating factor 1 receptor 5
- Bromodomain-containing protein 4 4
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 4
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 4
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 4
- Tissue-type plasminogen activator 3
- Plasminogen 3
- Vitamin K-dependent protein C 2
- Histone deacetylase 11 2
- Platelet-derived growth factor receptor alpha 2
- ATP-dependent translocase ABCB1 2
- Histone acetyltransferase KAT2B 2
- Histone acetyltransferase KAT2A 2
- Ephrin type-B receptor 2 2
- DCN1-like protein 2 2
- DCN1-like protein 5 2
- DCN1-like protein 4 2
- Broad substrate specificity ATP-binding cassette transporter ABCG2 2
- DCN1-like protein 3 2
- Diacylglycerol O-acyltransferase 2 2
- Envelope glycoprotein gp160 2
- Vascular endothelial growth factor receptor 3 2
- Vascular endothelial growth factor receptor 1 2
- Tyrosine-protein kinase BTK 1
- Cytochrome c oxidase subunit 2 1
- Macrophage-stimulating protein receptor 1
- Cytochrome c oxidase subunit 1 1
- Histone deacetylase 6 1
- Tyrosine-protein kinase receptor TYRO3 1
- Tyrosine-protein kinase receptor UFO 1
- ...
Publications 34▿
- US Patent US10227342 (2019) 400
- Eur J Med Chem 46: 2011-21 (2011) 161
- Bioorg Med Chem 13: 6693-702 (2005) 74
- J Med Chem 65: 163-190 (2022) 73
- Bioorg Med Chem Lett 10: 217-21 (2000) 68
- Bioorg Med Chem Lett 18: 2544-8 (2008) 64
- J Med Chem 65: 6207-6230 (2022) 62
- Bioorg Med Chem Lett 18: 1331-5 (2008) 60
- J Med Chem 49: 3402-11 (2006) 60
- J Med Chem 46: 681-4 (2003) 53
- J Med Chem 52: 7778-87 (2009) 49
- Bioorg Med Chem Lett 18: 3852-5 (2008) 48
- US Patent US9346818 (2016) 42
- J Med Chem 59: 6772-90 (2016) 41
- Eur J Med Chem 241: (2022) 41
- Bioorg Med Chem Lett 12: 1671-4 (2002) 39
- Eur J Med Chem 209: (2021) 38
- Eur J Med Chem 209: (2021) 33
- ACS Med Chem Lett 11: 188-194 (2020) 31
- Eur J Med Chem 194: (2020) 28
- US Patent US10800764 (2020) 23
- J Med Chem 64: 15503-15514 (2021) 22
- US Patent US10071991 (2018) 18
- US Patent US11214566 (2022) 18
- US Patent US9701638 (2017) 16
- J Med Chem 60: 4657-4664 (2017) 13
- ACS Med Chem Lett 3: 411-415 (2012) 13
- Bioorg Med Chem Lett 25: 2425-8 (2015) 10
- J Med Chem 61: 6308-6327 (2018) 7
- J Med Chem 56: 3414-8 (2013) 7
- Bioorg Med Chem Lett 21: 1422-4 (2011) 4
- US Patent US9611259 (2017) 3
- Bioorg Med Chem 22: 1383-93 (2014) 2
- Bioorg Med Chem Lett 26: 2434-7 (2016) 2
Institutions 25▿
- Ariad Pharmaceuticals 400
- Chinese Academy Of Sciences 161
- Johnson & Johnson Pharmaceutical 134
- Zhengzhou University 111
- Aventis Pharmaceuticals 92
- Rhone-Poulenc Rorer 68
- Johnson & Johnson Prd 64
- Central China Normal University 63
- Shanghai Institute Of Materia Medica 62
- Janssen Pharmaceutica 62
- Johnson & Johnson Pharmaceutical Research & Development 60
- Bristol-Myers Squibb Research And Development 49
- Johnson & Johnson Pharmaceutical Research And Development 48
- Novartis Institutes For Biomedical Research 44
- Zhejiang Hisun Pharmaceutical 42
- East China University Of Science And Technology 41
- Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University) 33
- College Of Pharmacy Of Liaoning University 28
- TBA 20
- Rutgers, The State University of New Jersey 16
- Sichuan University 10
- Chonnam National University 7
- Global Discovery Chemistry 4
- Nankai University 2
- China Pharmaceutical University 2
Affinity: 0.0020 to 5.9E+5 nM▿
- Ki 232
- IC50 1444
- Kd 20
- EC50 2
- Affinity ≤ nM
Xtal structures: 30
Docked structures: 8
Catalog Cmpds: 91