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TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141059(CHEMBL289614 | L-162782 | N-Butyloxycarbonyl-4'-(2...)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049189(3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049195(3-[(2'-(butylsulfonylcarbamate)-3'-propyl-1,1'-bip...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049189(3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50141059(CHEMBL289614 | L-162782 | N-Butyloxycarbonyl-4'-(2...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049195(3-[(2'-(butylsulfonylcarbamate)-3'-propyl-1,1'-bip...)
Affinity DataIC50:  4.20nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041561(CHEMBL3358422)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Leu-AMC as substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041558(CHEMBL2042018)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041562(CHEMBL3358423)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041563(CHEMBL3358424)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Arg-AMC as substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041559(CHEMBL3358420)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553093(CHEMBL4762305)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50041560(CHEMBL3358421)
Affinity DataIC50:  61nMAssay Description:Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataIC50:  251nMAssay Description:Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Leu-AMC as substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553092(CHEMBL4753417)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553095(CHEMBL4745618)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553096(CHEMBL4787513)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553091(CHEMBL4778960)
Affinity DataIC50:  2.06E+3nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50549530(CHEMBL4788892)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataIC50:  7.94E+4nMAssay Description:Inhibition of ERAP1 (unknown origin) using Leu-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553090(CHEMBL4744066)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor antagonist protein(Homo sapiens)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50553094(CHEMBL4761376)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full length human IRAP expressed in HEK293T cells assessed as substrate cleavage using Leu-MCA as substrate by fluorogenic ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50030814(CHEMBL2086892)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 3 mins followed by NADPH addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed